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Angiotensin II raises blood pressure by tightening blood vessels At a glance The published maximum daily dose for lisinopril is 80 mg per day for the treatment of high blood pressure and 40 mg per day for the treatment of heart failure. Zestril is also used to treat congestive heart failure in adults, or to improve survival after a heart attack. Maximum dose: 40 mg orally once a day. Lisinopril, combined with other drugs like diuretics, is also prescribed for patients with congestive heart failure. Pregnancy, breastfeeding and fertility It is used as adjunctive therapy in the treatment of heart failure. Lisinopril oral tablet is used to treat hypertension (high blood pressure) and heart failure. Cooper WO, Hernandez-Diaz S, Arbogast PG, et al. Warnings Do not use Zestril if you are pregnant. Both angiotensin I and angiotensin II are hormones. Using a free GoodRx coupon is a great way to save money on your prescription of lisinopril. 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