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For cold sores Aciclovir 400mg Tablets Effective Anti-Viral Cold Sore Treatment 310 people reviewed this product Cost-effective anti-viral treatment for outbreaks of cold sores. Use: For the treatment of herpes simplex labialis (cold sores). Acyclovir is a medication used to manage and treat infections caused by the herpes simplex virus (HSV). Aciclovir is also available as a cold-sore cream for the lips and face, and as an ophthalmic ointment for eye infections. It is also used to prevent having regular outbreaks of genital herpes. Acyclovir will not get rid of the virus infection but does help sores heal faster and helps with pain relief. 99 Aciclovir is a medicine that prevents the spread of viruses and is usually used to treat cold sores or herpes. Pregnancy, breastfeeding and fertility Acyclovir is an antiviral drug, often used to treat the herpes simplex virus that causes cold sores. 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